4/30/2023 0 Comments Nerve conduction test for sciaticaThe nociceptive response to thermal stimulus (tail flick test) and sciatic nerve conduction velocity (NCV) were recorded at the end of study. Changes in body weight, fasting blood glucose (FBG), glucose tolerance, and blood biochemical parameters were measured. The diabetic rats were orally administered with Viphyllin containing not less than 30% β-caryophyllene (BCP), at 25 mg, 50 mg and 100 mg/kg/day doses for 6 weeks. Methods: Type 2 diabetes was induced in male Wistar rats using high fat diet and a single dose of streptozotocin (60 mg/kg i.p.). Here, we have investigated for the first time the therapeutic effects of a standardized Piper nigrum L., (black pepper) seed extract, Viphyllin TM in mitigating hyperglycemia and neuropathic pain of type 2 diabetes model rats. Purpose: Research on plant-based formulations has drawn considerable attention in the management of diabetic neuropathy (DN) for having lesser side effects than the synthetic counterparts. Illuri Ramanaiah, Heggar Venkataramana Sudeep, Kodimule Shyamprasadĭepartment of Preclinical Studies, R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, Karnataka, 560 105, IndiaĬorrespondence: Heggar Venkataramana Sudeep, Department of Preclinical Studies, R&D Center for Excellence, Vidya Herbs Pvt Ltd, Bangalore, Karnataka, 560 105, India, Tel +91 80-42094158, Email
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